مجله دانشگاه علوم پزشکی جیرفت
سال هفتم شماره 2 (تابستان 1399)

The term diabetes heart in diabetic patients includes pathologic left ventricular hypertrophy. Stimulation of the signaling and molecular pathways of cardiac myocardial remodeling through exercise in this regard can be considered as a therapeutic strategy for physiological development of the left ventricle. In the present study, the effect of 8 weeks of high intensity interval training on protein kinase B (AKT) gene expression, insulin resistance level, heart weight, glucose and serum insulin in male Wistar rats with type 2 diabetes. 

Twenty male wistar rats, 10 weeks old, weighing 220±20gr were randomly divided into two groups: HIIT group and control group. After familiarization, the training group participated in an 8-week protocol, 5 sessions per week, for 30 minutes per session. To check the AKT gene expression and the variables serum levels, RT-PCR method and ELISA method were used. The data were analyzed by t-test for independent groups at p<0.05 level

It was observed that in the HIIT group, AKT expression was significantly higher than that of the control group (p<0.01). Exercise also significantly decreased insulin resistance (p<0.001) and serum glucose index (p<0.001), while serum insulin increased significantly (p<0.05) in association with this decrease. Rats weight in the training group also increased compared to the control group (p<0.05).

HIIT exercise increases the expression of AKT gene, stimulates the physiological molecular pathway of hypertrophy and plays a role in preventing left ventricular hypertrophy as a complementary treatment.

Diabetes is a multifactorial metabolic disorder characterized by chronic hyperglycemia. Type 2 diabetes is the most common type of diabetes and is the main cause of nephropathy, neuropathy, retinopathy and 60% cause of foot amputation, so this is an expensive disease.The aim of this study was to investigating and comparing of the diabetic patients' care between the Family Medicine Specialist Clinics (FMSCs) versus Family Medicine general Clinics.

254 patients with type 2 diabetes enrolled in this descriptive-analytic study. 64 cases selected from the family medicine specialist clinic (43 female, 21 male) and 190 patients from Family Medicine general Clinics (97 female, 93 male). Patients were 30 years or older and it had been at least two years since diagnosis of type 2 diabetes.

The efficacy of the family medicine specialist clinic was significantly better than the family medicine general clinics in management of the body mass index (p<0.001), blood pressure measurements (p<0.001), foot observation (p<0.01), sensory and vascular foot examination (p<0.01) and micro albuminuria measurement(p<0.01) There was no significant difference between mean of BMI, glycosylated hemoglobin, fasting blood sugar (FBS), two-hour blood sugar and systolic blood pressure in two groups

The results of current study showed that the efficacy of family medicine specialist clinic in diabetic care was higher than family medicine general clinics.

Physical activity plays an undeniable role in accelerating the recovery and prevention of complications in hypertensive patients. The purpose of this study was to determine factors affecting physical activity in hypertensive patients using Health Action Process Approach (HAPA) model in 2019-2020.

By convenience sampling, 176 hypertensive patients from the health care centers of Astaneh-ye Ashrafiyeh city were selected to participate in this descriptive cross-sectional study. Data were measured by demographic information questionnaire, International Physical Activity Questionnaire and HAPA Model related Scales. Data were analyzed using AMOS 22.0 software and chi-square, independent t-test, Pearson correlation coefficient and path analysis.

Intention, coping self-efficacy, action self-efficacy, and outcome expectancies were significantly correlated with physical activity (p<0.05). Also, action self-efficacy, outcome expectancies, perceived risks had significant effect on intention (p<0.01). Moreover, the path coefficient between intention (p<0.05) and coping self-efficacy (p<0.01) with physical activity behavior was significant. Finally, the HAPA model fitted well to the data and its constructs described 45% and 31% of the variance in intention and physical activity behavior, respectively.

The results emphasized the role of psychological variables such as action self-efficacy, coping self-efficacy, outcome expectancies and perceived risks in regular physical activity and also suggested the use of HAPA model for explaining factors affecting regular physical activity in hypertensive patients.

Adrenal gland cysts with variable symptoms are rare cases of over-kidney clinical conditions. Adrenal cysts are accidentally identified, which is referred to as incidentaloma. Adrenal cysts are non-specific and show radiological findings and Detection of these cysts is usually random. In this article,  a patient with a simple adrenal cyst is introduced

The patient is a 33-year-old woman with a severe abdominal complaint, especially in the upper and lower abdomen, which began one day before the visit. The patient also mentioned three vomiting episodes. CT scan of a multicellular cystic mass in the upper left abdomen was observed with calcified nodules near the pancreatic tail, which, according to the radiologist, suggested a possible false cysts of the pancreas. With the diagnosis of adrenal mass, surgery was performed and symptoms were resolved after surgery.

Undoubtedly, the current elimination of the mass of the current treatment and the laparoscopic adrenalectomy, if available, is the golden standard. This was a simple adrenal cyst, which was associated with non-specific digestive symptoms. Preoperative diagnosis was performed by CT and ultrasound. A laparoscopic adrenalectomy was performed without complications. Pathology was a simple adrenal cyst. However, when managing an adrenal cyst, adrenocarcinoma and cystic pheochromocytoma should be considered before surgery

Although the prevalence of adrenal cysts is rare, intervention is necessary if they are large (size>4), symptomatic, functional, and potentially malignant. Laparoscopic management of these cysts in the form of decoration / extension, safe, effective, with minimal invasion, minimal blood loss and shorter hospital stay.

Currently, a combination of drug and psychological therapies is common to treat and prevent relapse in addicts. One of the most important strategies for recovery and prevention of relapse is psychological therapy and maintenance therapy applying drugs such as methadone. Therefore, the present study compares the effect of cognitive-behavioral and methadone therapy combination therapy with the association of narcotics anonymous addicts on the executive functions of quitting drugs volunteer addicts in Jiroft.

The present study was a quasi-experimental (semi-experimental) posttest with a control group.  On this regard, 40 patients with substance abuse cases who had referred to addiction treatment centers were selected by available sampling method and randomly divided into two groups: A) Cognitive-behavioral combination therapy combined with methadone maintenance therapy and B) The control group was appointed. The third group included 20 people who referred to the association of narcotics anonymous addicts. After the intervention, the subjects completed the London Tower test. Data were analyzed using SPSS software version 20 and descriptive statistical methods and analysis of variance.

Data analysis showed that there was a difference in executive functions between two treatment groups of the association of narcotics anonymous addicts and combination therapy (p<0.05). There is also a difference in the executive functions between control group and two therapeutic groups (p<0.05).

Combination therapy and the association of narcotics anonymous addicts are effective in improving the executive functions of addicts’ drug quitting. However, the association of narcotics anonymous addict has made further improvements in these functions.

Stroke is a neurological disease and one of the leading causes of death all over the world. It is also an important cause of disability in people over age over 65. It may be possible to reduce the incidence of cerebral ischemia using antioxidants, followed by inhibition of oxidative and inflammatory mechanisms. Troxerutin is a natural bioflavonoid with antioxidant and anti-inflammatory properties. However, its neuroprotective effects have not yet been studied. The present study aimed to investigate the effect of troxerutin on ischemic brain damage in male mice.

In this experimental study, 39 male mice (30-25 grams) were used. The animals were divided into three groups: 1. Sham group 2. Ischemic brain group 3. The ischemic brain group, receiving troxerutin drug. Cerebral ischemia was induced in the second and third groups of mice. Five hours later, group 3 received 300 mg/kg troxerutin intraperitoneal injection. After 24 and 48 hours, the effect of troxerutin on sensory and motor neurological disorders, cerebral edema, and infarct volume was investigated. Analysis of variance test was performed by SPSS software (21) using one-way and two-way.

The results indicated that troxerutin reduced stroke volume (p=0.05) and cerebral edema (p=0.05) compared with the control group. Troxerutin also improved sensory-motor function (p<0.0001) and balance function and muscle strength (p<0.05)

Treatment with troxerutin can have beneficial effects on complications and disorders caused by cerebral ischemia.

Colon cancer is the fourth cause of mortality at the world and second common cancer in the Europe. About 8% of all cancer deaths are due to colon cancer. This condition is caused by abnormal growth of cells which can invade or multiply in other tissues of the body (metastasis). The present study was designed to investigate the Simultaneous effect of quercetin and exercises on oxidative stress induced by colon cancer In the heart tissue in animal models.

In this experimental study a total of 80 rats were divided into two groups, including control (n=10) and treated group (n=70). Cancer in rats is induced by subcutaneous injection of azoxy methane and then the cancer rats were randomly divided into seven experimental groups including, patient, saline, quercetin, continuous exercise, interval exercise, continuous exercise with quercetin, and interval exercise with quercetin. Oxidative stress including superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) were measured in the heart tissue using specific ELISA kits. Data were analyzed using ANOVA program by SPSS software.

Quercetin supplementation alone or in combination with exercise trainings significantly increased the mean of cardiac CAT and SOD activity compared to the treated group and saline groups (p<0.001), while MDA level was significantly decreased (p<0.05).

Colon cancer increases the oxidative stress of heart cells. Although quercetin alone has an anti-oxidative properties, combined therapy with interval and continuous training can be probably more effective.

Deep heated oils produce toxins which endanger people's health. Octopamine as an antioxidant supplement and aerobic exercise as a practical method can also improve health. The aim of this study was to investigate the effect of 4 weeks of aerobic and octapamine training on the amount of malondialdehyde and caspase 3 in the brown adipose tissue of male rats fed with deep heated oils.

In one experimental trial of 40 male Wistar rats after four weeks being feed with heated oil in five groups of 8, were selected as a statistical sample and randomly divided into groups: control-poisoning, exercise-poisoning, supplement-poisoning, Supplement-Exercise-Poisoning and Control-Health were divided. The 4 week training program, with 50 to 65 percent vo2max intensity on the treadmill, was three sessions a week for 20 minutes. Octopamine was used as a supplement for 4 weeks and 5 days a week using a dose of 81 μmol / kg as an intraperitoneal injection. ELISA Assay and Caspase 3 IHC immunohistochemistry were used to evaluate malondialdehyde

Due to deep-poisoned oil poisoning, the concentration of malondialdehyde increased significantly (p<0.001). Exercise significantly reduced the concentration of malondialdehyde (p<0.001). Ectapamine supplementation also reduced the concentration of malondialdehyde (p<0.001). The interaction of octapamine training and supplementation was also significant and decreased malondialdehyde concentration (p<0.05). Aerobic exercise had a significant effect on Caspase 3 concentration (p<0.001). Intake of octopamine supplementation also had a significant effect on Caspase 3 concentration (p<0.001). The interaction of aerobic exercise and octopamine also significantly reduced caspase 3 (p<0.05).

Aerobic exercise and octopamine reduce the destructive effects of deeply heated oils. Octopamine as an antioxidant and aerobic exercise as an important factor maintains the structure and function of brown adipose tissue.